与瘤相关的调节性T细胞的依赖于空气的胸膜发育
Sven Malchow1, Daniel S Leventhal, Saki Nishi
1Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
Science (New York, N.Y.)
|March 9, 2013
概括
研究人员发现了一种特定类型的调节性T细胞 (Treg),其向的是前列腺相关的抗原,而不是瘤特定的抗原. 这些细胞通过自身免疫调节器 (Aire) 途径在胸腺中发展,并且在前列腺瘤中发现.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- T细胞生物学T细胞生物学
背景情况:
- 与瘤相关的Foxp3(+) 调节性T细胞 (Tregs) 对治疗有兴趣,但它们的发育起源和抗原特异性尚不清楚.
- 了解Treg发育对于癌症免疫治疗至关重要.
研究的目的:
- 调查与瘤相关的Tregs的发育起源和抗原识别.
- 为了识别前列腺瘤中富含Tregs识别的特定抗原.
主要方法:
- 在前列腺癌小鼠模型中识别和表征抗原特异性Tregs (MJ23 Tregs).
- 与自身免疫调节 (Aire) 途径相关的Treg发育的分析.
- 通过MJ23 Tregs对抗原识别的评估.
主要成果:
- 在前列腺瘤中发现了抗原特异性Tregs (MJ23 Tregs) 的内源性种群.
- MJ23 Tregs识别了一种与前列腺相关的抗原,这种抗原存在于瘤携带和无瘤的小鼠中,而不是瘤特异性抗原.
- MJ23 Treg的发育依赖于胸腺中的自身免疫调节器 (Aire).
结论:
- 外周组织抗原的以空气为媒介的表达驱动器官特异性Tregs的胸膜发育.
- 瘤可能会将这些自然存在的,特定器官的Tregs用于自身利益.
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