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Updated: May 13, 2026

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Comparing the Affinity of GTPase-binding Proteins using Competition Assays

Published on: October 8, 2015

蛋白质组学的GTP亲和力探测器突出显示了纯氨酸核酸选择性的灵活性

Elizabeth A George Cisar1, Nhan Nguyen, Hugh Rosen

  • 1The Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|March 12, 2013
PubMed
概括

研究人员开发了一种新的GTP亲和探针,用于使用质谱测量来识别GTP结合蛋白. 该工具有助于发现未知的蛋白质标,并了解它们的核酸选择性.

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相关概念视频

GTPases and their Regulation02:14

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins, also known...