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DNA复制起源许可证的ATPase依赖质量控制

Jordi Frigola1, Dirk Remus, Amina Mehanna

  • 1Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK.

Nature
|March 12, 2013
PubMed
概括

精确的DNA复制依赖于加载Mcm2-7 DNA酶. 一个保存的Mcm3域通过刺激ORC-Cdc6 ATPase活性来招募Mcm2-7到起源,确保每细胞周期只发生一次复制.

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