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Updated: Jan 30, 2026

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在HNF-4α核受体复合体结构中的多域集成

Vikas Chandra1, Pengxiang Huang, Nalini Potluri

  • 1Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, USA.

Nature
|March 15, 2013
PubMed
概括

肝细胞核因子4α (HNF-4α) 结构揭示了突变如何导致糖尿病. 翻译后的修改和域连接会影响DNA结合,为代谢疾病提供新的治疗点.

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