在有机 mitra 反中右心室缩功能:双心室损伤的影响
Thierry Le Tourneau1, Guillaume Deswarte, Nicolas Lamblin
1Inserm, UMR 1087, Institut du thorax, Nantes, France. thletourneau@yahoo.fr
Circulation
|March 15, 2013
概括
右心室喷射分数 (EF) 损伤在有机 mitra 反中很常见,并且与左心室问题有关. 损伤的RV功能显著影响长期生存,特别是双心室功能障碍.
科学领域:
- 心脏病学 心脏病学
- 心脏成像 - - 心脏成像
- 这是心脏衰竭.
背景情况:
- 右心室 (RV) 喷射分数 (EF) 损伤是有机 mitra 反的一个重要问题.
- 评估RV EF患病率,决定因素和预后价值对于患者管理至关重要.
研究的目的:
- 为了评估RV射出分数 (EF) 损伤在有机 mitrale 吐患者的患病率,决定因素和预后意义.
- 调查RV功能障碍对心血管和整体存活时间的影响.
主要方法:
- 对208名患有慢性有机 mitra 反症的患者进行了心声学和双心室放射性核素血管学.
- 区域功能评估和病理生理学相关的分析,包括左心室功能和肺动脉静脉压.
- 长期心血管和整体存活率与RV EF和双心室功能障碍相关分析.
主要成果:
- 平均VREF为40.4±10.2%,30%的患者出现严重损伤 (≤35%).
- 主要确定RV EF的因素是左心室隔膜功能,终端透气直径和肺动脉静脉压.
- 在患有初始抑郁症的患者中,RV EF在手术后显著改善 (P<0.0001).
- RV EF ≤35% 降低了10年心血管存活率 (71.6% vs 89.8%,P=0.037).
- 双性损伤大大减少了10年心血管疾病 (51.9%对90.3%,P<0.0001) 和整体存活率 (34.8%对72.6%,P=0.003).
结论:
- 右心室功能障碍在有机 mitra 反中很常见,主要受到左心室重塑和隔膜功能的影响.
- RV功能作为术后心血管存活的预测指标.
- 双损伤是这组患者心血管和整体存活率的强有力的预测因素.
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