相关实验视频

Updated: May 13, 2026

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers

Published on: March 6, 2009

个体CD8+T细胞的异质分化模式

Carmen Gerlach¹, Jan C Rohr, Leïla Perié

¹Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.

Science (New York, N.Y.)

|March 16, 2013

概括

个体CD8(+) T细胞对感染表现出不同的反应,影响免疫力. 在T细胞反应中的可复制性来自于平均许多细胞的多样性行为,而不是单一的单个细胞作用.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
T细胞生物学T细胞生物学

背景情况:

CD8 ((+) T细胞反应对适应性免疫非常重要.
这些反应通常在感染后表现出可重现的膨胀和收缩模式.
这种可重复性被认为源于单个单个细胞的均行为.

研究的目的:

为了研究个体CD8的异质性 ((+) T细胞的反应.
为了确定单个T细胞在克隆扩张和分化过程中是否表现均.
了解单个T细胞对原发性和召回性免疫保护的贡献.

主要方法:

在体内追踪单个小鼠CD8 (((+) T细胞的血统.
追踪具有相同T细胞受体的T细胞后代.
分析T细胞后代对免疫记忆的差异性贡献.

主要成果:

单独的CD8 ((+) T细胞,即使具有相同的T细胞受体,也表现出异质的克隆扩张和分化.
单个原始T细胞的后代对短期和长期免疫有不同的贡献.
尽管总体可复制的人口级响应,但仍观察到这种异质性.

结论:

CD8(+) T细胞异质性是内在的,不仅仅是由不对称的分裂驱动的.
CD8(+) T细胞反应的可复制性是人群平均化的新兴属性.
个体T细胞变异显著影响免疫记忆和保护的发展.

更多相关视频

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8⁺ T Cell Responses

Published on: May 6, 2019

Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry

Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry

Published on: March 5, 2019

相关概念视频

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...