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In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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通过单个基因的多个突变在多个特征的适应性进化.

Catherine R Linnen1, Yu-Ping Poh, Brant K Peterson

  • 1Department of Biology, University of Kentucky, Lexington, KY 40506, USA. catherine.linnen@uky.edu

Science (New York, N.Y.)
|March 16, 2013
PubMed
概括

在内布拉斯加州的沙丘上,由自然选择驱动的鹿鼠进化出更轻的外套以进行伪装. 这种适应涉及Agouti基因内的多个突变,最大限度地减少有害副作用并促进局部适应.

科学领域:

  • 进化生物学是进化的生物学.
  • 遗传学 是一个遗传学.
  • 动物颜色动物的颜色.

背景情况:

  • 适应性表型变化是由精确的突变驱动的.
  • 了解这些突变是进化机制的关键.
  • 鹿鼠的外套颜色变化与它们的环境有关.

研究的目的:

  • 为了研究鹿鼠中浅色外套颜色的遗传基础.
  • 为了确定光色对捕食者的选择性优势.
  • 了解多种突变如何促进局部适应.

主要方法:

  • 使用塑模型评估掠食性的实地研究.
  • 在混杂的鹿鼠群中分析颜色变异.
  • 鉴定了与外套颜色特征相关的Agouti locus内的遗传区域.

主要成果:

  • 浅色的外套颜色提供了显著的选择性优势,对视觉狩猎的捕食者.
  • 轻松的沙丘表型是由多个不同的特征组成的.
  • 在Agouti位点内对多个突变的独立选择驱动了局部适应.

结论:

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  • 鹿鼠的局部适应是Agouti locus内多个突变的独立选择的结果.
  • 每个突变对适应性表型都有特定的影响,最大限度地减少了类的后果.
  • 这种机制允许在没有重大权衡的情况下进行适应.