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Updated: May 13, 2026

Synthesis of an Intein-mediated Artificial Protein Hydrogel
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激发了人造蛋白质水凝,支持生物活性蛋白质的固定

Miguel Ramirez1, Dongli Guan, Victor Ugaz

  • 1Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843, USA.

Journal of the American Chemical Society
|March 21, 2013
PubMed
概括

研究人员开发了一种新型的自组装蛋白质水凝,采用了分裂蛋白技术. 这种稳定,可回收的水凝为组织工程,药物输送和生物催化剂提供了新的可能性.

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Matrix Proteoglycans and Glycoproteins

Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...