18至50岁的成年人中中风后的长期死亡率
Loes C A Rutten-Jacobs1, Renate M Arntz, Noortje A M Maaijwee
1Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
JAMA
|March 21, 2013
概括
经历中风的年轻人长期死亡风险明显较高. 这项研究发现,18至50岁的人群中急性中风后的20年死亡率与一般人群相比大幅增加.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 年轻成年人 (18-50岁) 首次中风后的长期死亡率数据有限,特别是在非缺血性中风方面.
- 以前的研究往往排除了预期的死亡率,可能高估了中风的特定风险.
研究的目的:
- 调查18-50岁成年人中急性中风后的长期死亡率和死亡原因.
- 将观察到的死亡率与年龄和性别匹配的全国死亡率进行比较.
主要方法:
- 一项前性队列研究 (FUTURE研究),959名患者首次经历过渡性缺血性发作 (TIA),缺血性中风或脑内出血.
- 平均随访时间为11.1年的评估生存状况,使用标准化死亡率 (SMRs) 将观察到的死亡率与预期的死亡率进行比较.
主要成果:
- 在30天生存者中,20年累积死亡率为TIA的24.9%,缺血性中风的26.8%,脑内出血的13.7%.
- 观察到的死亡率明显高于预期,SMR从2.6 (TIA) 到3.9 (缺血性中风和脑内出血) 之间.
- 对于缺血性中风,男性的死亡风险比女性高.
结论:
- 与普通人群相比,年轻成年人 (18-50岁) 在急性中风后面临相对较高的20年死亡风险.
- 研究结果强调了对年轻中风幸存者加强二次预防策略的必要性.
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