不同的神经通路组装一个行为状态从焦虑中可分离的特征
Sung-Yon Kim1, Avishek Adhikari, Soo Yeun Lee
1Department of Bioengineering, Stanford University, Stanford, California 94305, USA.
Nature
|March 22, 2013
概括
终端的床核 (BNST) 协调焦虑特征. 不同的BNST亚区域产生相反的效果,其中脊前BNST投射通过特定的神经回路调解焦虑解.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 焦虑研究 焦虑研究
背景情况:
- 哺乳动物的焦虑状态涉及到行为和生理特征的协调调节.
- 中枢神经系统,特别是特定的大脑区域,协调这些不同的焦虑表现.
- 了解焦虑背后的神经回路对于开发有针对性的治疗干预至关重要.
研究的目的:
- 为了调查来自单个大脑区域的神经投射,末端 (BNST) 的床核,如何调解各种焦虑特征.
- 确定BNST中涉及焦虑调节的特定子区域和不同的途径.
- 阐明BNST组装焦虑状态的电路机制.
主要方法:
- 在小鼠中整合行为分析,体内和体外电生理学和光遗传学.
- 呼吸系统生理学和行为选择模式的分析.
- 在体内记录自由移动动物在暴露于不同环境中的神经元活动.
主要成果:
- 两个BNST亚区域表现出相反的效果:圆BNST促进了焦虑特征,而背脊BNST表现出解焦虑效应.
- 三个不同的背前BNST不同投射差异化介导焦虑症:降低风险回避 (侧向下丘脑),降低呼吸速率 (近脊核) 和增加阳性价值 (腹膜区域).
- 电路元件的选择性抑制和激发产生了相反的行为结果,脊椎前BNST神经元与焦虑性环境安全区分开来.
结论:
- 不同的BNST子区域在调节焦虑方面起着相反的作用.
- 特定的背前BNST投射介导可分离的抗焦虑效应,突出功能专业化.
- 这项研究说明了新的电路机制,这些机制是焦虑相关的行为和生理特征的协调组合的基础.
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