怀孕期间母亲的维生素D状况与后代的骨矿物质含量相关:一项前性队列研究
Debbie A Lawlor1, Andrew K Wills, Abigail Fraser
1MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol UK. d.a.lawlor@bristol.ac.uk
Lancet (London, England)
|March 23, 2013
概括
怀孕期间母亲的维生素D水平不会影响后代在童年后期的骨矿物质含量. 这项大规模的研究发现,母亲的25OH) D状况与儿童的骨健康之间没有显著的关联.
科学领域:
- 人体生理学 人体生理学
- 营养科学 营养科学
- 儿科健康 儿科健康
背景情况:
- 怀孕期间母亲的维生素D状况被假设会影响后代的骨矿物质含量 (BMC).
- 此前关于这种关联的研究受到小研究规模的限制.
- 这项研究调查了大规模前性队列中的联系.
研究的目的:
- 为了检查妊娠期间母亲血清25-基维生素D [25(OH) D]度与9-10岁后代BMC之间的关联.
- 为了确定不同季度母亲的维生素D水平是否会影响后代的骨发育.
主要方法:
- 利用了阿文长度研究的父母和孩子的数据,包括3960对母子对.
- 通过双能X射线吸收计测量孕期和后代的孕产妇25(OH) D水平,测量全身减去头部 (TBLH) 和脊柱 BMC.
- 分类的母体25(OH) D充足 (>50.00nmol/L),不足 (27.50-49.99nmol/L),或缺乏 (<27.50nmol/L).
主要成果:
- 在有足够,不足或缺乏维生素D水平的母亲的后代之间,没有观察到TBLH或脊柱BMC的显著差异.
- 包括第三个三个月在内的妊娠三季度的分析显示,与后代的BMC没有任何关联.
- 对TBLH和脊椎BMC每10.0nmol/L增加的母体25(OH) D的调整后的平均差异可以忽略不计.
结论:
- 怀孕期间母亲的维生素D状况不是儿童晚期后代骨矿物质含量的重要决定因素.
- 这些发现表明,专注于母体维生素D改善儿童骨健康的干预措施可能不有效.
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