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Updated: May 13, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
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在血清素受体的功能选择性的结构特征

Daniel Wacker1, Chong Wang, Vsevolod Katritch

  • 1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|March 23, 2013
PubMed
概括

素酸二甲基胺和相关化合物在5-HT2B受体上显示偏差信号,激活β-arrestin通路. 结构研究揭示了G蛋白结合受体 (GPCRs) 中这种功能选择性的基础.

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