急性淋巴细胞白血病急性淋巴细胞白血病
Hiroto Inaba1, Mel Greaves, Charles G Mullighan
1Department of Oncology, St Jude Children's Research Hospital and University of Tennessee Health Science Center, Memphis, TN 38105, USA. hiroto.inaba@stjude.org
Lancet (London, England)
|March 26, 2013
概括
儿童急性淋巴细胞白血病的存活率现在是90%,但新的遗传见解对于改善婴儿和成人的结果至关重要. 个性化医疗为更好的治疗和减少副作用提供了希望.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 儿科血液学/瘤学
背景情况:
- 急性淋巴细胞白血病 (ALL) 是一种常见的儿童癌症,原因多重.
- 儿科ALL的存活率显著改善,在临床试验中达到约90%.
- 然而,对于ALL的婴儿和成年人来说,预后仍然很差,需要创新的治疗策略.
研究的目的:
- 审查目前对ALL病变发生,治疗进展和未来方向的理解.
- 突出基因分析在识别新亚型和治疗点方面的作用.
- 强调需要新的方法来提高生存率和减少不良影响,特别是在高风险群体.
主要方法:
- 关于急性淋巴细胞白血病流行病学,治疗和遗传学的现有文献的综述.
- 对儿科ALL的生存数据和风险分层策略的分析.
- 讨论全基因组分析技术,用于识别白血病细胞中的遗传变化.
主要成果:
- 由于风险分层,个性化治疗修改 (药理动力学和药理基因组学) 以及增强的支持性护理,儿童ALL生存率有所改善.
- 全基因组DNA分析揭示了新的遗传变化,有助于白血病发生和定义新的疾病亚型.
- 这些遗传发现为个性化医学提供了潜在的预后标志物和治疗点.
结论:
- 虽然儿科ALL的存活率很高,但需要进一步的进展,特别是对于婴儿和成年人.
- 基因分析对理解ALL的复杂性和开发有针对性的疗法至关重要.
- 个性化医疗方法有望改善治疗结果并尽量减少ALL治疗中的毒性.
更多相关视频
06:41Identification of Quiescent Cells in a Zebrafish T-Cell Acute Lymphoblastic Leukemia Model Using Cell Proliferation Staining
Published on: July 19, 2024
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
相关概念视频
01:27Disorders of Leukocytes
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...