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相关概念视频

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...

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相关实验视频

Updated: May 12, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
07:08

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

Published on: February 2, 2024

在癌症中的表观遗传重编程.

Mario L Suvà1, Nicolo Riggi, Bradley E Bernstein

  • 1Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Science (New York, N.Y.)
|March 30, 2013
PubMed
概括

由转录因子和染色体调节器驱动的细胞状态过渡,为癌症发育和干细胞模型提供了洞察力. 了解这些机制是再生医学和瘤学的关键.

科学领域:

  • 细胞生物学 细胞生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 在瘤学瘤学.

背景情况:

  • 诱导多能性和直接血统转换揭示了转录因子和染色质调节者的细胞状态转换中的作用.
  • 这些过程对再生医学和理解癌症发展有影响.

研究的目的:

  • 审查细胞状态过渡和瘤发生之间的概念平行.
  • 突出转录因子,染色体调节剂和癌症中的表观遗传状态之间的相互关系.

主要方法:

  • 文献综述和概念分析.
  • 细胞重编程和癌症生物学中的机制的比较分析.

主要成果:

  • 确定了涉及转录因子,染色体调节器和表观遗传状态的共享机制.
  • 这些共享的途径揭示了瘤转变和瘤异质性.

结论:

  • 了解细胞状态过渡机制为癌症干细胞模型提供了洞察力.
  • 这些发现通过强调共同的监管原则,将再生医学和癌症研究联系起来.

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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

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相关实验视频

Last Updated: May 12, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
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Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018