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Updated: May 12, 2026

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尼龙-3聚合物具有选择性抗真菌活性.

Runhui Liu1, Xinyu Chen, Zvi Hayouka

  • 1Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

Journal of the American Chemical Society
|April 4, 2013
PubMed
概括

新的尼龙-3聚合物表现出强烈的抗真菌活性,对白 Candida,同时对哺乳动物细胞和红细胞的毒性较低. 这一突破为开发选择性抗真菌剂提供了一个有希望的途径.

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...