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Updated: May 12, 2026

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

早期的造血细胞祖先的多样化和可遗传的血统印记

Shalin H Naik1, Leïla Perié, Erwin Swart

  • 1Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. naik.s@wehi.edu.au

Nature
|April 5, 2013
PubMed
概括

造血干细胞 (HSC) 和淋巴原始多能原始细胞 (LMPP) 在体内表现出不同的命运. 细胞条形码显示,血统印记发生的时间比以前想象的要早,支持了血液形成的分级承诺模型.

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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