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Updated: May 12, 2026

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在白血病细胞中向抑制突变IDH2会诱导细胞分化

Fang Wang1, Jeremy Travins, Byron DeLaBarre

  • 1Agios Pharmaceuticals, Cambridge, MA 02139-4169, USA.

Science (New York, N.Y.)
|April 6, 2013
PubMed
概括

一个新的小分子,AGI-6780,可以选择性地抑制突变异酸盐脱酶2 (IDH2/R140Q),这是某些癌症的关键驱动因素. 这种向抑制显示出在癌症治疗中差异化疗法的潜力.

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