关节动物中心复合体和脊椎动物基底的深度同质性
Nicholas J Strausfeld1, Frank Hirth
1Department of Neuroscience, School of Mind, Brain and Behavior, University of Arizona, Tucson, AZ 85721, USA. flybrain@neurobio.arizona.edu
概括
关节动物中心复合体和脊椎动物的基底格lia具有共同的深层进化起源和电路相似性. 这些大脑区域调节适应性行为,它们的功能障碍会导致类似的运动和认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 比较生物学的比较生物学
- 进化生物学 进化生物学
背景情况:
- 关节动物中央复合体和脊椎动物的基本格lia是关键的大脑结构参与行为.
- 这两种结构都源于保存的胚胎基底前脑谱系.
- 遗传程序指定相互连接的中线前脑 - 中脑边界核.
研究的目的:
- 为了研究节肢体中央复合体和脊椎动物的基底质之间的深层同质性.
- 为了比较这两个大脑区域之间的遗传,结构和功能相似性.
- 了解行为调节的进化基础.
主要方法:
- 对遗传程序和谱系规范进行比较分析.
- 对神经解剖学组织和连接性的检查.
- 抑制性 (GABAergic) 和调节性 (dopaminergic) 电路作用的功能性比较.
主要成果:
- 这两种结构都来自于保存的胚胎基底前脑谱系.
- 在这两种情况下,网络连接和神经元活动都调节了适应性行为.
- 这两种功能障碍都会导致类似的行为缺陷 (运动,记忆,注意力,影响,睡眠).
结论:
- 关节动物中心复合体和脊椎动物的基本质电路之间提出了深层同源性.
- 这些保存的电路是行为行为的选择和维护的基础.
- 了解这些相似之处可以了解大脑功能和行为的演变.
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