患有细菌性脑膜炎的成年人的内心炎
Marjolein J Lucas1, Matthijs C Brouwer, Arie van der Ende
1Academic Medical Center, Center of Infection and Immunity Amsterdam, Department of Neurology.
Circulation
|April 19, 2013
概括
由内心炎 (心脏内膜炎) 复杂的细菌性脑膜炎不常见,但会导致频繁的并发症和不良结果. 这项研究在2%的细菌性脑膜炎病例中发现了内心炎.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 神经学 神经学
背景情况:
- 细菌性脑膜炎可能会因内心炎而复杂化,但这种共同发生的频率和影响尚未得到充分确定.
- 了解细菌性脑膜炎中内心炎的发生率和临床影响对于患者管理至关重要.
研究的目的:
- 为了确定内心炎的发病率和临床特征,在社区获得的细菌性脑膜炎的成年患者.
- 调查与共存脑膜炎和内心炎相关的结果和并发症.
主要方法:
- 从2006年到2012年,荷兰进行了一项全国性的队列研究,分析了社区获得的细菌性脑膜炎的成年患者.
- 内心炎是根据临床线索确定的,包括心脏声,持续发烧,心脏门疾病史,以及特定的致病原体,如金黄色葡萄球菌.
主要成果:
- 在2%的细菌性脑膜炎发作中 (24在1025中) 诊断出内心炎.
- 常见的致病原体包括肺炎链球菌和金黄色葡萄球菌.
- 观察到系统性 (70%) 和神经性 (54%) 并发症的高率,其中63%的患者经历了不利的结果和29%的死亡率.
结论:
- 内心炎是细菌性脑膜炎的罕见但显著的并发症.
- 细菌性脑膜炎和内心炎的同时发生与严重并发症和不良结果的高发病率有关.
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