人类乳头瘤病毒和子宫癌
Emma J Crosbie1, Mark H Einstein, Silvia Franceschi
1Institute of Cancer Sciences, University of Manchester, Oxford Road, Manchester, UK.
Lancet (London, England)
|April 27, 2013
概括
持续高风险的人类乳头瘤病毒 (HPV) 感染会导致各种癌症. HPV 疫苗和检测是可以拯救全球生命的关键预防策略.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 子宫癌主要是由持续高风险的人类乳头瘤病毒 (HPV) 感染引起的,特别是HPV 16型.
- HPV感染上皮细胞,破坏细胞循环的控制,导致不受控制的细胞分裂和遗传损伤.
研究的目的:
- 审查人类乳头瘤病毒 (HPV) 在癌症发展中的作用.
- 突出预防性疫苗和HPV检测在癌症预防策略中的重要性.
主要方法:
- 审查有关HPV感染,病变和预防的现有文献.
- 对HPV疫苗和HPV检测在初级和二级预防中的临床实用性的分析.
主要成果:
- 已有两种有效的预防性HPV疫苗 (针对HPV 16/18和HPV 16/18/6/11) 在发达国家可供使用.
- HPV检测对于二次预防,细胞鉴定和治疗的测试是有价值的,比细胞学提供更高的灵敏度,并允许延长查间隔.
结论:
- 预防性HPV疫苗接种和HPV检测是预防HPV相关癌症的关键初级和二级预防策略.
- 在发展中国家实施这些预防策略有可能挽救许多人的生命.
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