结核病的激进宿主特异性疗法
Jeroen W J van Heijst1, Eric G Pamer
1Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. vanheijj@mskcc.org
Cell
|April 30, 2013
概括
高水平的瘤亡因子 (TNF) 可以使结核病恶化,导致感染的巨细胞死亡,导致细菌扩散. 这项研究揭示了过度的TNF如何触发细胞死亡并促进疾病的进展.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 细胞生物学 细胞生物学
背景情况:
- 促炎性细胞因子,如瘤亡因子 (TNF),对于控制Mycobacterium结核病感染至关重要.
- 然而,TNF的过度产生可以悖论地恶化结核病理.
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