可生物降解的核心外载体,用于同时封装协同作用的活性物质
Maike Windbergs1, Yuanjin Zhao, John Heyman
1School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. m.windbergs@mx.uni-saarland.de
Journal of the American Chemical Society
|May 2, 2013
概括
研究人员开发了一种新的可生物降解的核心外载体,用于有效封装和释放协同作用的药物组合. 这种无溶剂的微流体技术精确地控制粒子特性,以改善癌症治疗的交付.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 同时封装多种协同作用的药物对于有效的组合疗法至关重要.
- 现有的载体系统在有效封装和精确比例下控制药物的释放方面扎.
研究的目的:
- 开发一种新的可生物降解的核心外载体系统,以高效地联合输送水友性和疏水性药物.
- 为了证明在新型载体中封装的协同作用的抗癌药物的受控释放和治疗疗效.
主要方法:
- 生物可降解的核心外载体的制造,使用单步,无溶剂的微流体工艺.
- 在水性核心中封装水友性多克索鲁比辛化,在固体外中封装水友性帕克利塔塞尔.
- 粒子大小,成分和药物加载效率的表征;在癌症细胞系中评估体外药物释放和疗效.
主要成果:
- 在核心外结构中实现了对水友性和水害性药物的高封装效率.
- 证明精确控制颗粒大小和组成.
- 展示了同步控制释放协同作用的抗癌药物,从而在癌症衍生细胞系中显著有效.
- 开发了一种稳定,可储存的药物载荷颗粒粉末配方.
结论:
- 这种新型生物降解的核心外载体系统提供了一个高效和精确的平台,用于共同提供协同作用的药物组合.
- 无溶剂的微流体制造方法为先进的药物输送应用提供了可扩展和多用途的方法.
- 这项技术具有显著的潜力,可以改善组合癌症疗法,并封装其他活性成分.
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