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拉A/C和埃梅林通过调节行为动态调节MKL1-SRF活动

Chin Yee Ho1, Diana E Jaalouk, Maria K Vartiainen

  • 1Cornell University, Weill Institute for Cell and Molecular Biology/Department of Biomedical Engineering, Ithaca, New York 14853, USA.

Nature
|May 7, 2013
PubMed
概括

在LMNA基因的突变导致拉米诺病,影响核包膜蛋白. 这项研究揭示了lamin A/C和emerin如何通过actin动态调节基因表达,从而影响心脏功能.

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