尿血中盐和水的保留和的阻塞
G M London1, S J Marchais, A P Guerin
1Centre Hospitalier F.H. Manhes Fleury-Merogis, Hospital Broussais, Paris, France.
Circulation
|July 1, 1990
概括
尼丁平在血液透析患者中有效降低血压,而不会导致低血压. 这种抗高血压作用在患有水分保留和改善动脉硬性和心脏功能的患者中更大.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 高血压是长期血液透析患者的常见并发症.
- 在这个人群中,控制血压和心血管风险因素至关重要.
研究的目的:
- 评估尼二平单一治疗对高血压血液透析患者的血压和动脉硬性的疗效和影响.
主要方法:
- 这是一项为期24周的双盲,安慰剂随机化研究,涉及40名高血压血液透析患者.
- 测量包括血压,心声学和脉冲波速度 (大动脉和外周).
主要成果:
- 尼丁平显著降低了血液透析前的血压,但没有导致透析后的低血压.
- 药物的效果在患有更大的透析间体重增加 (液体保留) 的患者中更为明显.
- 尼丁平降低了大动脉和大腿脉冲波速度,增加了左心室喷射率,与动脉硬性变化相关.
结论:
- 尼丁平是一种有效的抗高血压剂在血液透析患者,特别是那些流体保留.
- 治疗改善了动脉硬和左心室功能,而不仅仅是降低血压.
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