回复评论"证据表明,人类对最近获得的调节功能进行了丰富的净化选择"的评论
1Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
Science (New York, N.Y.)
|May 11, 2013
概括
我们完善了我们的方法,以确认ENCODE元素中的广泛的谱系特定约束. 我们的研究结果强调了参考选择对估计受约束核酸的影响.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 生物信息学是一种生物信息学.
背景情况:
- 了解基因组进化需要识别功能上受限制的区域.
- 恩科德项目已经绘制了人类基因组中的许多功能元素.
- 准确的方法对于量化进化约束至关重要.
研究的目的:
- 纳入并扩大对先前提出的评估谱系特定约束的方法的纠正.
- 重新评估和支持ENCODE元素中存在重大约束的最初结论.
- 澄清约束估计对参考数据集选择的依赖性.
主要方法:
- 纳入和扩展Green和Ewing提出的方法修正.
- 利用特定的受约束和中立的基因组参考进行分析.
- 在ENCODE元素中量化基系特定的约束.
主要成果:
- 改进的方法支持广泛的谱系特定约束的结论.
- 约束在ENCODE元素中高度集中.
- 约束核酸的数量对约束和中性引用的定义敏感.
结论:
- 这种精细的方法强大地识别了功能性基因组元素中的血统特定约束.
- 在ENCODE元素中,存在着相当大的进化约束.
- 仔细选择参考数据集对于基因组研究中准确的约束估计至关重要.
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