在生长中的蓝藻细菌中,强大的昼夜振荡需要转录反
Shu-Wen Teng1, Shankar Mukherji, Jeffrey R Moffitt
1Howard Hughes Medical Institute, Faculty of Arts and Sciences Center for Systems Biology, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
概括
菌的昼夜节律依赖于振荡的翻译后调节 (PTR). 转录-翻译反调节 (TTR) 对于保持这些生物体的个体振荡器稳定性和种群同步性至关重要.
科学领域:
- * 分子生物学 * 分子生物学
- * 系统生物学 系统生物学
- * * 时间生物学
背景情况:
- *循环节律是内生生物过程,调节日常循环.
- * 菌表现出强大的昼夜振荡,对于细胞过程至关重要.
- * 蓝藻细菌的昼夜时钟涉及复杂的调节机制.
研究的目的:
- * 为了研究后翻译调节 (PTR) 电路在产生蓝藻细菌中昼夜振荡方面的充分性.
- * 确定转录-翻译反调节 (TTR) 在维持振荡器稳定性和群体同步性方面的作用.
- * 模拟蓝藻细菌的昼夜钟,以了解PTR和TTR之间的相互作用.
主要方法:
- * 对蓝藻细菌昼夜时钟组件进行实验分析.
- * 对昼夜调节电路的数学建模.
- * 在不同的监管条件下研究振荡器稳定性和人群同步性.
主要成果:
- * 仅仅翻译后调节 (PTR) 电路就足以在生长中的蓝藻细菌中产生昼夜振荡.
- *由于没有转录-翻译反调节 (TTR),单个振荡器显示稳定性降低.
- * 在缺乏TTR的蓝藻细菌中,没有保持种群同步,这是实验数据和建模所证明的.
- *数学建模证实了PTR电路中的持续振荡,并突出了TTR对同步的重要性.
结论:
- * 后翻译调节 (PTR) 电路是蓝藻细菌昼夜时钟的核心组成部分.
- *转录-翻译反调节 (TTR) 在稳定个体昼夜振荡器和确保群体同步方面发挥着至关重要的作用.
- * PTR和TTR的组合确保了蓝藻细菌的稳健和同步的昼夜行为.
相关概念视频
Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Prokaryotic Transcriptional Activators and Repressors
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
Transcription of prokaryotic...
Prokaryotic Transcriptional Activators and Repressors
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
Transcription of prokaryotic...
Biological Clocks and Seasonal Responses
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Global Regulatory Systems
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...


