在基因相同的小鼠中出现个性
Julia Freund1, Andreas M Brandmaier, Lars Lewejohann
1CRTD-DFG Research Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany.
Science (New York, N.Y.)
|May 11, 2013
概括
鼠标探索活动的个体差异随着年龄的增长而增加,这与大脑可塑性有关. 这项研究模拟了环境因素如何塑造动物独特的大脑发育和行为.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 行为遗传学 行为遗传学
- 动物模型 动物模型
背景情况:
- 在动物模型中捕捉大脑可塑性作为个性的反映是具有挑战性的.
- 人类双胞胎研究表明,发育因素有助于个体差异.
研究的目的:
- 开发一种动物模型来研究大脑可塑性的个体差异.
- 为了研究探索性行为与小鼠海马神经发生之间的关系.
主要方法:
- 收集了40只在丰富环境中的内生小鼠的纵向活动数据.
- 分析了随着时间的推移探索活动和漫游的个体差异.
- 与成人海马神经发生相关的行为数据.
主要成果:
- 随着时间的推移,老鼠的探索活动有所不同,随着年龄的增长,个体差异越来越大.
- 漫游的个体差异与海马神经发生有正相关.
- 发育因素导致大脑可塑性和行为的个体差异.
结论:
- 开发的范式可以作为识别可塑性机制的模型.
- 这种模型可以阐明非共享的环境贡献对个体行为差异.
相关概念视频
01:16In-vitro Mutagenesis
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...