相关实验视频
Updated: May 6, 2026

12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 27, 2013
33.7K
单个纯粹的CD4+ T细胞从多样化的剧目中产生不同的效应细胞类型在感染期间
Noah J Tubo1, Antonio J Pagán, Justin J Taylor
1Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Cell
|May 14, 2013
概括
单个T细胞对微生物的反应各不相同,但总的来说,它们保持着对效应细胞的一致比例. 这种分工受到T细胞受体 (TCR) 信号强度和-MHCII相互作用的影响.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- T细胞分化的特异化
背景情况:
- 纯粹的CD4 ((+) 特定于微生物:主要基因相容性复合物II联体 (p:MHCII) 的T细胞种群对于适应性免疫至关重要.
- 这些群体通常包括许多细胞,每个细胞都表达一种独特的T细胞受体 (TCR).
- 感染后,出现一定的效应细胞比例来激活巨细胞或协助B细胞产生抗体.
研究的目的:
- 为了研究在天真T细胞群体内效应细胞分化和分工的潜在机制.
- 了解个体T细胞的行为如何对总体人群反应作出贡献.
主要方法:
- 追踪单个天真T细胞的后代,以分析它们的分化模式.
- 与T细胞受体 (TCR) -p:MHCII停留时间和p:MHCII丰度相关联的效应细胞生产比率.
主要成果:
- 单个的天真T细胞产生了不同比例的巨细胞和B细胞辅助效应细胞.
- 当平均各种单个细胞行为时,总人口产生了特征性的效应细胞比率.
- 效应器细胞模式与TCR-p:MHCII停留时间和p:MHCII的数量相关,表明TCR信号强度影响差异化.
结论:
- 在多克隆的天真T细胞群体中,一致的效应细胞子集比率是由单个克隆的不同反应的平均值产生的.
- 由TCR-p:MHCII相互作用调节的TCR信号强度,在指导T细胞分化和分工方面发挥着关键作用.
相关概念视频
Cell-mediated Immune Responses
65.0K
Overview
65.0K
Cells of the Adaptive Immune Response
6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
T Cell Activation and Clonal Selection
13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K
T Cell Types and Functions
3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
Cytotoxic T Cells-mediated Immune Response
7.1K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.1K
Immune Response Against Viral Pathogens
2.4K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.4K

