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治疗双相情感障碍的治疗方法
John R Geddes1, David J Miklowitz1
1Department of Psychiatry, University of Oxford, Oxford, UK (Prof J R Geddes MD, Prof D J Miklowitz PhD); and Division of Child and Adolescent Psychiatry, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA, USA (Prof D J Miklowitz PhD).
Lancet (London, England)
|May 14, 2013
概括
双相情感障碍治疗的进步在药物方面显示出适度的收益,但在心理社会干预方面有显著的前景. 未来的创新需要针对个性化护理的综合神经生物学和心理社会方法.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 心理治疗 心理治疗
背景情况:
- 双极性障碍治疗的进展仍然很小,特别是在药物治疗方面.
- 抗精神病药物在急性躁狂症中表现出有效性,在抑郁症中产生不同的结果.
- 在双极性抑郁症中使用抗抑郁药仍然存在争议;是预防复发的最佳方法.
研究的目的:
- 审查近期急性和长期双相情感障碍治疗的进展.
- 确定未来治疗创新的有希望的途径.
- 探索药理和心理社会干预措施的整合.
主要方法:
- 对近期双相情感障碍治疗进展的文献综述.
- 对药物疗效的证据分析 (抗精神病药,抗抑郁药,抗药).
- 评估辅助心理社会干预措施及其与药物治疗的结合.
主要成果:
- 抗精神病药物对急性躁狂是有效的; 奎蒂亚平显示出对双极性抑郁症最明显的证据.
- 证明了最强的长期复发预防证据.
- 心理社会干预,结合药物,增强长期维持和急性抑郁稳定.
结论:
- 未来的双相情感障碍治疗应该整合神经生物学和心理社会机制.
- 优化药物和心理治疗治疗的结合是非常重要的.
- 了解治疗对睡眠和昼夜节律的影响可以个性化护理;心理治疗需要提高效率.
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