通过封装和疾病触发释放MRI剂的集体激活
Mathieu L Viger1, Jagadis Sankaranarayanan, Caroline de Gracia Lux
1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California, 92093, USA.
Journal of the American Chemical Society
|May 16, 2013
概括
超微型的加多氧化物纳米粒子 (Gd氧化物NP) 被封装在生物反应性聚合物囊中. 这些囊在响应疾病标志物时释放NP,激活强烈的MRI对比度增强.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 氧化物纳米粒子 (Gd氧化物NP) 是潜在的MRI对比剂.
- 由于屏蔽,它们的放松性在水性环境中经常被抑制.
- 生物响应材料提供有针对性的交付和激活策略.
研究的目的:
- 使用生物反应性聚合物囊开发超小Gd氧化物NP的激活机制.
- 为了在对疾病特异性化学标记的反应中实现触发的Gd氧化物NP释放.
- 在NP激活时显著增强MRI对比度.
主要方法:
- 在疏水性聚合物矩阵中封装超小的Gd氧化物NP.
- 聚合物囊的设计响应酸性pH和过氧化 (H2O2).
- 在囊拆卸后评估NP释放和放松性变化.
主要成果:
- 在高分子囊中成功封装和屏蔽了gd氧化物NP.
- 囊的拆卸和NP释放是由酸性pH和H2O2.2.触发的.
- 在激活时,实现了>1级的对比度增强.
结论:
- 开发的系统可以控制激活Gd氧化物NP用于MRI.
- 生物反应性囊有效地屏蔽和释放对比剂,以应对疾病标志物.
- 这种方法为有针对性和增强的MRI对比度生成提供了一个有希望的策略.
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