单独或联合使用的特里巴和德诺苏马布,治疗绝经后骨质疏松症妇女: DATA研究随机试验
Joy N Tsai1, Alexander V Uihlein, Hang Lee
1Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Lancet (London, England)
|May 21, 2013
概括
结合teriparatide和denosumab可显著提高患有骨质疏松症的绝经后妇女的骨矿物质密度 (BMD),为高危骨折患者提供了一个有前途的新治疗策略.
科学领域:
- 内分泌学和骨代谢 骨质代谢
- 对骨质疏松症的药理干预措施
背景情况:
- 骨质疏松症药物可以改善骨矿物密度 (BMD),但不能完全减轻骨折风险.
- 以前试图将合成代谢剂与双酸盐结合在一起的尝试并没有提高疗效.
- 这项研究调查了与单独治疗相比,结合特里巴和德诺苏马布的疗效.
研究的目的:
- 为了比较teriparatide和denosumab联合药物的疗效与在绝经后患有骨质疏松症的女性中的单独药物的疗效.
- 评估组合治疗对各种骨部位的骨矿物质密度 (BMD) 的影响.
主要方法:
- 一项随机对照试验,涉及患有骨质疏松症的绝经后妇女.
- 参与者被分配每天接受特里巴拉提德,每6个月服用登索马布,或两者的组合.
- 骨矿物质密度 (BMD) 在基线和3,6,12个月后进行测量.
主要成果:
- 组合组在12个月后,与单独使用特里巴或德诺苏马布相比,腰椎骨髓 BMD 的增加显著增加.
- 腿部部和全部BMD也显示了与单一治疗相比,组合治疗的改善显著更大.
- 94%的符合条件的女性完成了至少一次研究访问,确保了可靠的数据进行分析.
结论:
- 与单独使用的任何药物相比,结合的特里巴和德诺苏马布治疗导致BMD的提升.
- 这种组合疗法可能为骨质疏松症患者提供更有效的治疗选择,而骨折风险较高.
- 这些发现表明,骨质疏松症管理的潜在进展超出了目前批准的治疗方法.
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