在低温下对胺和胺进行基质催化双功能添加. 碳烯化的新途径
Jeremy M John1, Satoshi Takebayashi, Nupur Dabral
1Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.
Journal of the American Chemical Society
|May 22, 2013
概括
诺约里催化剂的脱增强了其在低温下化胺和胺碳基的活性. 这项研究详细介绍了催化剂.
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
- 不对称的合成方法
背景情况:
- 诺约里催化剂对于不对称的化非常重要.
- 胺基和胺基化仍然具有挑战性.
- 基于的催化剂为碳降解提供了潜力.
研究的目的:
- 为了合成和描述新的诺约里催化剂衍生物.
- 为了研究这些衍生物在化胺和胺中的催化活性.
- 阐明在中周期性物质的脱对称化过程中存在的异构选择机制.
主要方法:
- 诺约里酸化催化剂转化[RuH2((R) -BINAP) (((R,R) -dpen) ] (1a) 的单质和二质化.
- (8-K) 和 (8-Li, 8-M'2) 金属化复合物的合成.
- 在低温下在THF-d8中测试胺基和胺基碳酸的化活性.
- 详细分析半循环性伊米德脱对称的对抗选择来源.
主要成果:
- 合成了新的合金复合物 (8-K, 8-Li, 8-M'2).
- 这些复合物在低温下表现出前所未有的胺基和胺基碳基化活性.
- 催化剂8-K在中周期性物质的脱对称化中表现出高的反选择性.
- 在THF-d8的低温条件是这种催化转换的最佳条件.
结论:
- 诺约里催化剂的脱化显著增强了其活性,并将其基质范围扩大到胺基和胺基.
- 开发的复合物是低温化反应的高效催化剂.
- 了解 enantioselection 机制为设计未来不对称催化剂提供了洞察力.
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