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Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
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描述细胞染色体P450 3A4的膜结合状态:结构,插入深度和方向

Javier L Baylon1, Ivan L Lenov, Stephen G Sligar

  • 1Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Journal of the American Chemical Society
|May 24, 2013
PubMed
概括

研究人员研究了细胞染色体P450 3A4 (CYP3A4) 的膜结合状态,这是一个关键的药物代谢酶. 模拟和实验揭示了其在细胞膜内的特定插入深度和方向,这对于理解药物相互作用至关重要.

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