在前额叶皮层的两个内部神经元类型的明显的行为和网络相关物
D Kvitsiani1, S Ranade, B Hangya
1Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Nature
|May 28, 2013
概括
在大脑中的帕瓦尔胺 (PV) 和索马托斯塔丁 (SOM) 神经元.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 计算神经科学是一种神经科学.
背景情况:
- 前额叶皮层神经元表现出不同的行为角色,可能是由于细胞类型的差异.
- 了解神经元类型是将网络功能与行为联系起来的关键.
研究的目的:
- 在奖励食任务中调查前带皮层中parvalbumin (PV) 和somatostatin (SOM) 内神经元在奖励食任务中发挥的不同作用.
- 为了确定这些特定的神经元类型如何在食行为中的决策过程中发挥作用.
主要方法:
- 从基因识别PV和SOM神经元的电生理学记录在小鼠中执行奖励食任务.
- 分析神经元活动与特定的行为事件相关的分析,如奖励接近和离开.
- 描述PV和SOM神经元对主要细胞的抑制作用.
主要成果:
- PV和SOM神经元的一个亚型在行为和抑制中表现出不同的,分离的作用.
- 在奖励接近时,SOM神经元选择性地作出反应,而PV神经元在奖励离开时作出反应,并编码了之前的停留时间.
- PV神经元具有快速,强大的抑制作用,而SOM神经元具有较弱,更可变的抑制作用.
结论:
- 内部神经元的PV和SOM亚型在调节信息流和食过程中的决策方面发挥着功能上不同的作用.
- 细胞类型的多样性对在行为过程中在皮质电路中观察到的功能多样性有显著的贡献.
- 这些发现将特定的内部神经元类与前带皮层在食和决策中的关键功能联系起来.
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