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Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
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由RIP1驱动的自身炎症针对IL-1α,独立于炎症和RIP3的炎症体

John R Lukens1, Peter Vogel, Gordon R Johnson

  • 1Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Nature
|May 28, 2013
PubMed
概括

蛋白氨酸酸酶SHP-1中的突变会导致严重的炎症. 免疫细胞通过受体相互作用蛋白1 (RIP1) 调节的IL-1α产生驱动这种慢性炎症性疾病,独立于炎症细胞.

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