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Updated: May 10, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

53BP1通过不同的蛋白相互作用来调解生产性和变异性DNA修复

Elsa Callen1, Michela Di Virgilio, Michael J Kruhlak

  • 1Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

Cell
|June 4, 2013
PubMed
概括

DNA损伤反应 (DDR) 蛋白53BP1管理着DNA修复途径. 通过RIF1和PTIP对53BP1的酸化明显地控制了DNA修复,促进了免疫球蛋白类开关重组 (CSR) 并抑制了突变性修复.

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