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病的重要性不断变化:从子专业到全球卫生负担
Kai-Uwe Eckardt1, Josef Coresh, Olivier Devuyst
1Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany. kai-uwe.eckardt@uk-erlangen.de
Lancet (London, England)
|June 4, 2013
概括
慢性病 (CKD) 影响超过10%的人口,与功能下降和白尿有关. 早期检测和专业合作对于管理这种公共卫生负担至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 遗传学 是一个遗传学.
背景情况:
- 慢性病 (CKD) 是一个重要的全球健康问题,在一般人群中患病率超过10%,在高危人群中超过50%.
- 慢性瘤的关键指标,包括减少的膜过率 (GFR) 和增加的尿蛋白分泌量,与临床预后有很强的关联.
- 脏在维持身体平衡中起着至关重要的作用,并且可以影响系统性疾病,突出显示它们的重要性不仅仅是目标器官.
研究的目的:
- 为了突出病对公共卫生的影响.
- 为了强调GFR和白蛋白尿在CKD的预后意义.
- 强调脏在全身健康中的作用以及脏疾病的遗传基础.
主要方法:
- 关于CKD流行率的流行病学数据的审查.
- 分析GFR,白蛋白尿和临床结果之间的关联.
- 检查导致病的遗传因素.
- 评估脏在全身病理生理学中的作用.
主要成果:
- 在全球范围内,CKD的患病率超过10%,在高风险人群中增加超过50%.
- 降低的GFR和增加的白蛋白尿是对CKD预后的一致,独立的预测因素.
- 急性GFR降低是不良结果和CKD进展的危险因素.
- 遗传因素提供了对脏异常和恒温过程的见解.
结论:
- 慢性瘤是一个重大的公共卫生挑战,需要客观的诊断措施.
- GFR和白蛋白尿是评估CKD预后和进展的关键生物标志物.
- 脏的系统影响和遗传基础需要综合保健方法来预防和管理.
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