在患有严重心力衰竭的患者中,在前臂运动期间肌肉血液流动
J M Arnold1, J P Ribeiro, W S Colucci
1University of Western Ontario, London, Canada.
Circulation
|August 1, 1990
概括
慢性心力衰竭 (CHF) 中的肌肉疲劳不是由于运动肌肉的血流受损. 运动期间前臂血流在心脏病患者和健康人群之间是相似的,这表明血管功能正常.
科学领域:
- 心血管生理学心血管生理学
- 运动生理学 运动生理学
背景情况:
- 肌肉疲劳是慢性心力衰竭 (CHF) 患者的常见症状.
- 潜在的原因可能涉及肌肉血管系统炼血管扩张能力的异常.
研究的目的:
- 调查CHF肌肉疲劳是否是运动期间局部血流调节受损的结果.
- 为了比较前臂血流 (FBF) 在运动期间在严重的CHF患者与健康对照.
主要方法:
- 在15%,30%和45%的最大自愿收缩中,在间歇性前臂静态运动期间使用中的张力计静脉囊造影来研究FBF.
- 在休息和运动期间,对13名心血管疾病患者和8名健康人进行了测量.
- 在静脉注射milrinone24小时后,CHF患者被重新评估.
主要成果:
- 与对照组相比,CHF患者的休息FBF显著较低 (p < 0.05).
- 在运动期间,FBF在任何强度的CHF患者和对照人群之间没有显著差异.
- 峰值运动FBF与中央静脉压负相关 (r = -0.65),与右心室喷射率 (r = 0.59) 有正相关.
结论:
- 在患有严重心血管衰竭的患者中,运动前臂肌肉血管系统的血管扩张能力似乎正常.
- 肌肉疲劳在CHF不太可能源于局部血管对运动反应的内在异常.
- 血液动力学因素,如中央静脉压力和右心室功能,可能会影响心血管衰竭的运动能力.
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