子体内血管支架的肝素耐药血栓形成. 通过合成抗血素的中断
W C Krpski1, A Bass, A B Kelly
1Department of Basic and Clinical Research, Scripps, Clinic and Research Foundation, La Jolla, California.
Circulation
|August 1, 1990
概括
金属支架增加了移植中的血小板沉积,在血管塑性手术后存在血栓形成的风险. 氨酸在模型中没有减少这种血小板积累,这表明它在预防支架血栓形成方面的有效性有限.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 血栓形成的研究研究
背景情况:
- 血管收窄和闭塞经常发生在血管塑性和内关节切除术后.
- 内血管支架用于较大的血管血管形成术,但与急性血栓形成有关.
- 金属网状内置假体可以触发血栓形成.
研究的目的:
- 为了评估与移植中的内血管支架相关的血栓形成.
- 为了比较肝素和D-FPRCH2Cl的抗血栓疗效.
- 评估扩展聚四乙烯 (ePTFE) 移植体内的不同类型的支架上的血小板沉积.
主要方法:
- 在身上使用了慢性外化动脉静脉性膠分流器.
- 嵌入了3毫米的ePTFE移植与内血管支架.
- 测量了急性血小板沉积,使用111氧化标记的血小板和1小时的玛摄像头成像.
主要成果:
- 与对照EPTFE移植相比,支架显著增加了血小板沉积 (p < 0.006).
- 气球可扩展和自我扩展的支架显示出类似的血小板积累.
- 系统性肝素治疗没有减少血小板沉积.
结论:
- 内血管支架在EPTFE移植中促进了显著的血小板沉积.
- 在这个模型中,肝素在防止支架相关血小板沉积方面表现出有限的有效性.
- 需要进一步的策略来缓解支架血栓形成.
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