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相关概念视频

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...

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相关实验视频

Updated: May 10, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

动态组合图书馆:从探索分子识别到系统化学.

Jianwei Li1, Piotr Nowak, Sijbren Otto

  • 1Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Journal of the American Chemical Society
|June 5, 2013
PubMed
概括

动态组合化学 (DCC) 使用相互转换的分子来发现像自我复制器这样的新型结构. 这种方法,即动态组合库 (DCL),为系统化学和分子机器提供了新的途径.

科学领域:

  • 化学 化学 化学
  • 超分子化学 超分子化学
  • 系统化学 系统化学

背景情况:

  • 动态组合化学 (DCC) 涉及到成员不断交换构建块的图书馆.
  • 动态组合图书馆 (DCL) 是发现意想不到的分子结构和功能的关键.
  • DCLs使分子网络中的新兴特性成为可能,在系统化学中开辟了新的可能性.

研究的目的:

  • 突出动态组合化学中的新方法.
  • 在热力学控制下分析DCL,用于合成和自组装中的应用.
  • 审查将DCC原则扩展到非平衡系统的高级功能.

主要方法:

  • 探索化学图书馆成员的动态互换.
  • 动态组合图书馆的热力学控制.
  • 将DCC原则应用于非平衡系统.

主要成果:

  • 发现了新型分子,包括互锁结构和自我复制器.
  • 合成受体,催化系统和超分子架构的开发.
  • 在非平衡系统中表现出更丰富的功能行为,例如自我复制和分子机器.

结论:

更多相关视频

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

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相关实验视频

Last Updated: May 10, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

  • DCL是分子发现和系统化学的强大工具.
  • 在DCL中的热力学控制产生了多样化的功能系统.
  • 将DCC扩展到非平衡系统可以解锁先进的分子功能.