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在病毒集成过程中,HIV-1通过DNA依赖蛋白激酶导致CD4细胞死亡

Arik Cooper1, Mayra García, Constantinos Petrovas

  • 1Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-3005, USA.

Nature
|June 7, 2013
PubMed
概括

通过DNA-PK激活,HIV-1整合会触发CD4 ((+) T细胞死亡. 整合酶抑制剂和DNA-PK干预可以改善感染个体的免疫功能.

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