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Updated: May 8, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

哺乳动物GIRK2-βγ G-蛋白复合体的X射线结构

Matthew R Whorton1, Roderick MacKinnon

  • 1Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.

Nature
|June 7, 2013
PubMed
概括

在结构上分析了细胞电刺激能力至关重要的G蛋白门内向整流器K ((+) (GIRK) 通道. 该研究揭示了G蛋白子单元如何与GIRK2通道结合,稳定预开状态并阐明通道激活机制.

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G-protein Coupled Receptors

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G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Interaction domains in cell signaling
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G Protein-coupled Receptors

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