基因皮质输入驱动了初级和高级视觉区域之间的遗传区别
Shen-Ju Chou1, Zoila Babot, Axel Leingärtner
1Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
概括
转录因子指定了早期视觉皮层. 然后,甲状腺轴突细化这些区域,将高阶视觉区域与V1区分开来,并实现特定的功能.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 皮层发育 皮层发育
背景情况:
- 新皮层区域模式是通过祖先转录因子理解的主要视觉区域 (V1).
- 从V1区分高阶视觉区域 (V(HO)) 的机制仍然不清楚.
研究的目的:
- 为了调查thalamocortical轴突 (TCA) 输入在区分V1和V(HO) 中的作用.
- 阐明视觉皮层区域模式的多阶段过程.
主要方法:
- 在体内被遗传删除的基因皮层TCA.
- 分析了V1和V(HO) 之间的模式基因表达差异.
主要成果:
- 需要基因皮质TCA输入来区分V1和VHO.
- TCA输入驱动所有层的基因表达模式.
- 这种输入对于建立区域特定的功能性质至关重要.
结论:
- 视觉皮层区域的模式包括一个两阶段的过程.
- 由原始转录因子的初始规范创建了一个尾场.
- 随后分化为V1和V(HO) 需要TCA输入用于遗传和功能专业化.
相关概念视频
Motor and Sensory Areas of the Cortex
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Vision
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
Association Areas of the Cortex
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Anatomy of the Eyeball
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
Somatosensory, Motor, and Association Cortex
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at the...
Visual System
Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
Once through the pupil, the light passes through the lens, a...


