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Updated: May 10, 2026

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通过分隔无意义介导的mRNA衰变来调节轴突引导

Dilek Colak1, Sheng-Jian Ji, Bo T Porse

  • 1Department of Pharmacology, Weill Medical College, Cornell University, New York, NY 10065, USA.

Cell
|June 11, 2013
PubMed
概括

无意中介衰变 (NMD) 通过控制mRNA稳定性来调节轴突中的局部蛋白质合成. 这种机制通过影响像Robo3.2.2这样的关键引导受体的表达来引导轴突路径.

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The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
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