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Updated: May 7, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

53BP1是DNA损伤诱导的H2A Lys 15泛素标记的读者

Amélie Fradet-Turcotte1, Marella D Canny, Cristina Escribano-Díaz

  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

Nature
|June 14, 2013
PubMed
概括

澄清了53BP1 (TP53BP1) 蛋白质对DNA双链断裂 (DSB) 位点的招募. 它可以识别特定的组合基因素标记,这是DNA修复过程中必不可少的.

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Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

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Visualization of DNA Repair Proteins Interaction by Immunofluorescence07:55

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Nucleotide Excision Repair

Overview
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Covalently Linked Protein Regulators

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
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Base Excision Repair

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