自体免疫性肝炎是一种自身免疫性肝炎
Michael A Heneghan1, Andrew D Yeoman, Sumita Verma
1Institute of Liver Studies, King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK.
Lancet (London, England)
|June 18, 2013
概括
自免疫性肝炎是一种免疫媒介性肝病,在大多数情况下可以有效治疗. 像肝移植这样的先进疗法为严重或末期肝病提供了解决方案.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 自身免疫性肝炎 (AIH) 是一种具有急性和慢性表现的肝包膜疾病.
- AIH与其他自身免疫性疾病具有共同的特征,包括非器官特异性抗体和肝脏自身免疫,使其病理生理学复杂化.
- 最近的研究强调了调节性T细胞在AIH病变发生中的作用.
研究的目的:
- 总结一下目前对自身免疫性肝炎的理解.
- 讨论诊断挑战和治疗策略.
- 强调考虑变异性综合征的重要性.
主要方法:
- 关于自身免疫性肝炎的最新科学文献的综述.
- 对疾病触发因素和遗传易感性数据的分析.
- 对治疗结果和移植疗效的评估.
主要成果:
- 在目前的治疗方法下,高达85%的患者获得临床和生化缓解.
- 替代性免疫抑制策略可用于非响应者.
- 肝移植对急性肝衰竭和肝细胞癌等末期疾病并发症非常有效.
结论:
- 自身免疫性肝炎是一种可管理的疾病,缓解率高.
- 遗传易感性和环境触发因素在疾病发展中起作用.
- 肝移植仍然是晚期疾病的关键选择.
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