过早生育的视网膜病变
Ann Hellström1, Lois E H Smith, Olaf Dammann
1Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Lancet (London, England)
|June 21, 2013
概括
在早产婴儿中早产儿视网膜病变源于视网膜神经血管生长中断. 优化氧气,营养以及胰岛素样生长因子1等关键因素可以预防严重的视力丧失.
科学领域:
- 眼科医生 眼科 眼科
- 新生儿科学 新生儿科学
- 发展生物学 发展生物学
背景情况:
- 早产新生儿的不成熟视网膜容易受到破坏神经血管生长的侮辱.
- 过早性视网膜病变 (ROP) 涉及停止的血管化 (第一阶段) 和随后的缺氧驱动的新血管化 (第二阶段).
- 控制氧气可以减少但不能消除ROP,因此需要确定其他有助于ROP的因素.
研究的目的:
- 识别导致早产发育视网膜病变的因素.
- 探索预防严重,危及视力的ROP及其并发症的策略.
- 在早产婴儿中促进正常的视网膜神经血管发育.
主要方法:
- 对早产病原的视网膜病变现有文献的综述.
- 分析过氧,母胎相互作用,缺氧和生长因素的作用.
- 讨论包括氧气,营养和特定因素正常化在内的预防策略.
主要成果:
- 过氧和被破坏的母胎相互作用阻止了视网膜血管化.
- 血管化不良的视网膜中的缺氧刺激了病理性血管扩散.
- ROP的发病是多因素的,涉及生长因素,氧气,营养,感染和炎症.
结论:
- 预防严重的ROP需要控制除氧气之外的因素,包括营养和必需的生长因素.
- 优化胰岛素样生长因子1和ω-3多不和脂肪酸至关重要.
- 抑制感染和炎症可以支持正常的神经血管发育,并限制ROP的进展.
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