Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity.

Nature·2026
Same author

Castor specifies NB5-2 late-born interneuron molecular identity and premotor connectivity.

Developmental biology·2026
Same author

Cell body clustering drives gap junction-mediated synchronous activity in command neurons.

bioRxiv : the preprint server for biology·2026
Same author

The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity.

eLife·2026
Same author

Vnd and En are expressed in orthogonal stripes and act in a brief competence window to combinatorially specify NB7-1 and its early lineage.

Developmental biology·2026
Same author

A conserved differentiation programme facilitates inhibitory neuron production in the developing mouse and human cerebellum.

Development (Cambridge, England)·2025

相关实验视频

Updated: May 10, 2026

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

在祖先中结合的时模式扩大了神经多样性.

Omer Ali Bayraktar1, Chris Q Doe

  • 1Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA.

Nature
|June 21, 2013
PubMed
概括

多虫中介神经祖先 (INPs) 通过表达特定的转录因子,顺序产生不同的神经亚型. 这种时间模式,与父母神经芽细胞活动一起,增加了成年人中枢复合体的神经多样性.

科学领域:

  • 发育生物学是发展生物学.
  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.

背景情况:

  • 人体外腹腔下部区域 (OSVZ) 神经前体和多索菲拉 II 型神经母细胞产生中介神经前体 (INPs).
  • 对于INP在神经细胞类型多样化中的作用尚不清楚.

研究的目的:

  • 为了研究INP是否扩大或多样化神经细胞类型.
  • 为了确定底层神经多样性生成的机制在Drosophila和潜在的人类.

主要方法:

  • 在Drosophila II型神经细胞系中对基因表达和后代的分析.
  • 在INPs中对转录因子Dichaete,Graniny head和Eyeless的功能研究.

主要成果:

  • 多虫INPs连续产生不同的神经亚型.
  • 序列表达的Dichaete,粒状的头,和无眼的转录因子是必要的亚型的生产.
  • 父母II型神经母细胞也表现出时间模式,产生多样化的神经/质后代.

结论:

  • 神经母细胞和INP中的时间模式协作增强成人中心复合体中的神经多样性.

更多相关视频

Time-lapse Live Imaging of Clonally Related Neural Progenitor Cells in the Developing Zebrafish Forebrain
07:49

Time-lapse Live Imaging of Clonally Related Neural Progenitor Cells in the Developing Zebrafish Forebrain

Published on: April 6, 2011

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
09:25

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Published on: June 4, 2014

相关实验视频

Last Updated: May 10, 2026

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

Time-lapse Live Imaging of Clonally Related Neural Progenitor Cells in the Developing Zebrafish Forebrain
07:49

Time-lapse Live Imaging of Clonally Related Neural Progenitor Cells in the Developing Zebrafish Forebrain

Published on: April 6, 2011

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
09:25

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Published on: June 4, 2014

  • 人类大脑中的OSVZ祖先也可能使用类似的机制来增加神经多样性.