在体感皮层中长距离投射神经元的行为依赖性招募
Jerry L Chen1, Stefano Carta, Joana Soldado-Magraner
1Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Nature
|June 25, 2013
概括
小鼠大脑中的神经通路根据行为不同地传递感官信息. 主体体感官皮层 (S1) 中明确的投射神经元选择性地将胡须相关的数据发送到运动和关联区域.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 皮层电路中的皮层电路.
背景情况:
- 哺乳动物新皮质依赖于分离的处理流来进行感官表现.
- 在行为过程中,从主要感官皮层传输到遥远区域的局部信息的传输仍然不太清楚.
研究的目的:
- 在行为过程中调查主要体感皮质 (S1) 中投射神经元的任务依赖激活.
- 为了确定信息是如何从S1选择性传输到二级体感官 (S2) 和初级运动 (M1) 皮层.
主要方法:
- 在清醒,表现的小鼠中进行双光子成像,执行纹理歧视和物体检测任务.
- 监测解剖学识别的S1神经元向S2或M1投射的神经元活动.
- 分析S2投射 (S2P) 和M1投射 (M1P) 神经元的任务依赖反应和区分能力.
主要成果:
- 在S2P神经元中发现了与鞭毛相关的细胞,但在M1P神经元中没有发现.
- 在S2P神经元显示更多的触摸反应在纹理歧视;在M1P神经元显示更多的位置检测.
- 无论是S2P和M1P神经元都在类似地歧视行为决策,但S2P神经元在纹理歧视方面表现出色,而M1P神经元在决策相同时在位置歧视方面表现出色.
结论:
- 选择性传输S1信息到S2和M1是由行为上下文驱动的,而不仅仅是感官特征.
- 在S1中,不同的投射神经元群体在传递不同行为目标的感官信息方面发挥着专门的作用.
相关概念视频
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Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
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The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the stimulus...
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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
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