基因和神经机制抑制了Drosophila与其他物种交配
Pu Fan1, Devanand S Manoli, Osama M Ahmed
1State Key Laboratory of Biomembrane and Membrane Biology, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
Cell
|July 2, 2013
概括
一个特定的化学受体,Gr32a和无果 (Fru(M)) 阻止雄性果求爱其他物种. 这些遗传机制通过抑制物种间求爱行为来确保生殖隔离.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 遗传学 是一个遗传学.
- 行为生态学 行为生态学
背景情况:
- 行为性生殖隔离对于维持物种完整性至关重要.
- 跨物种求爱通常很少发生,这表明先天的抑制机制.
研究的目的:
- 研究果中生殖隔离的神经和遗传基础.
- 为了确定防止跨物种求爱的特定分子通路.
主要方法:
- 在Drosophila melanogaster中利用了基因操纵和神经元活动记录.
- 研究了化学受体Gr32a和转录因子Fruitless (Fru(M)) 的作用.
- 研究了Gr32a和Fru(M) 神经元之间的神经回路相互作用.
主要成果:
- 化学受体Gr32a积极抑制雄性Drosophila melanogaster与其他果物种交配.
- 在Gr32a表达神经元中活动既必要又足以防止跨物种求爱.
- 无果 (Fru(M)) 也抑制了物种间的求爱,有证据表明涉及Gr32a神经元的共同神经电路.
- 不同的机制阻止了对同种雄性与其他物种的求爱.
结论:
- 一个涉及Gr32a和Fru(M) 调节基因的化学传感途径构成了抑制雄性果物种间求爱的关键机制.
- 这一途径似乎在其他雄性类动物中得到保护,有助于繁殖隔离.
- 虽然在女性中没有观察到这种情况,但这些发现强调了对特定物种求爱行为的遗传控制.
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